Cycloheximide solution, 100mg/mL in DMSO, 0.2 micron filtered

Catalog No.	Quantity
AAJ66004XF	1 mL

Catalog No. AAJ66004XF Supplier Thermo Scientific Chemicals Supplier No. J66004XF

Description

Cycloheximide, CAS # 66-81-9, is a compound produced by the bacterium Streptomyces griseus that shows an antifungal antibiotic activity with the ability to inhibit protein synthesis only in eukaryotic cells. | CAS: 66-81-9 | C15H23NO4 | 281.35 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Cycloheximide is a semisynthetic compound showing an antifungal antibiotic activity.
• It is produced by the bacterium Streptomyces griseus
• Cycloheximide can inhibit protein synthesis in eukaryotic cells but not in prokaryotes by interacting directly with the translocase enzyme and interfering with the translocation step. Furthermore, this compound also blocks the A site of ribosomes

Applications

• Cycloheximide shows a neuroprotective, fungicide, and anticoronaviral activities
• In biomedical research it can induce glycogenolysis, gluconeogenesis, and ureogenesis
• Due to significant toxic side effects such as teratogenesis, DNA damage, birth defects, and toxicity to sperm, this chemical compound is only used in in vitro research applications
• This compound also shows inhibitory activity against ferroptosis
• It is also used in laboratory media as a selective agent to permit the isolation of pathogenic and non-pathogenic fungi from other types of specimens
• In laboratory research related to plant biology it can induce ethylene production to promote the plant growth
• In laboratory research, this compound can be applied to determine the half-life of protein in any cellular system. The treatment of in vitro cells with cycloheximide in a time-course experiment followed by western blotting using this cell lysate can show differences in protein half-life.

Specifications

Chemical Identifiers

• CAS: 66-81-9
• Molecular Formula: C15H23NO4
• Molecular Weight (g/mol): 281.35
• MDL Number: MFCD00082346
• InChI Key: YPHMISFOHDHNIV-QTEFRXOUNA-N
• Synonym: CHX
• PubChem CID: 6197
• ChEBI: CHEBI:27641
• IUPAC Name: 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
• SMILES: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC1CC(=O)NC(=O)C1

• Type: Cycloheximide
• Physical Form: Liquid
• Color: Colorless to Yellow
• Quantity: 1 mL
• Flash Point: 87°0°C (230°F)
• UN Number: UN2810
• Formula Weight: 281.35
• Chemical Name or Material: Cycloheximide solution, 100mg/mL in DMSO, 0.2 micron filtered

Safety and Handling

Hazard Category	H227-H300-H341-H360D
Hazard Statement	GHS H Statement H300-H360-H341-H227 Fatal if swallowed. May damage fertility or the unborn child. Suspected of causing genetic defects. Combustible liquid.
Precautionary Statement	P201-P202-P210-P264b-P270-P281-P301+P310-P308+P313-P330-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 6.1; Packaging Group: II; Proper Shipping Name: TOXIC, LIQUIDS, ORGANIC, N.O.S.
EINECSNumber	200-636-0
RTECSNumber	MA4375000
TSCA	No
storageNote1	2° to 8°C
Recommended Storage	Keep cold

SDS

RUO – Research Use Only