Invitrogen™ Cyclophilin A Recombinant Rabbit Monoclonal Antibody (4L4U4)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA557931

Catalog No. MA557931

Description

Immunogen sequence: RIIPGFMCQG GDFTRHNGTG GKSIYGEKFE DENFILKHTG PGILSMANAG PNTNGSQFFI CTAKTEWLDG KHVVFGKVKE GMNIVEAMER FGSRNGKTSK.

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.

Specifications

• Antigen: Cyclophilin A
• Classification: Recombinant Monoclonal
• Concentration: 1.1 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P10111, P17742, P62937
• Gene Symbols: Ppia
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 55-154 of human Cyclophilin A (NP_066953.1).
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 4L4U4
• Conjugate: Unconjugated
• Gene: Ppia
• Gene Alias: 2700098C05; Cphn; CYCA; cyclophilin; Cyclophilin A; Cyclosporin A-binding protein; CyP A; CyP-18; CYPA; CyP-A; CYPH; EC 5.2.1.8; epididymis secretory sperm binding protein Li 69p; HEL-S-69p; HGNC:9253; I79_011869; MGC117158; MGC12404; MGC23397; p1B15; p31; Peptidyl-prolyl cis-trans isomerase A; Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; peptidylprolyl isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIA; PPIase; PPIase A; rotamase; rotamase A; SP18; T cell cyclophilin
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 25518, 268373, 5478
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid