Cyclophilin B Mouse anti-Human, Mouse, Rat, Clone: 8H4F1, Proteintech

Catalog No.	Quantity
50-173-6486	150 μL

Catalog No. 50-173-6486 Supplier Proteintech Group Inc Supplier No. 660471IG150UL

Description

Mouse Monoclonal Antibody

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP′s) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase′s, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.

Specifications

• Antigen: Cyclophilin B
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 8H4F1
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: PPIB
• Gene Accession No.: P23284, P24368, P24369
• Gene Alias: Cyclophilin B, CYP S1, CYPB, PPIase B, Rotamase B, S cyclophilin, SCYLP
• Gene Symbols: Ppib
• Host Species: Mouse
• Immunogen: Cyclophilin B Fusion Protein Ag17957
• Purification Method: Protein A
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19035, 5479, 64367
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a