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Cyclophilin B Recombinant Rabbit Monoclonal Antibody (ST05-22), Invitrogen™

Catalog No. PIMA532170
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PIMA532170 100 μL
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Catalog No. PIMA532170 Supplier Thermo Scientific Supplier No. MA532170

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cyclophilin B
Applications Western Blot
Classification Monoclonal
Clone ST05-22
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene PPIB
Gene Accession No. P23284, P24368, P24369
Gene Alias AA408962, AA553318, AI844835, Cphn2, Cphn-2, cyclophilin B, cyclophilin-like protein, Cyp B, CyP-20b, CYPB, CYP-S1, EC 5.2.1.8, epididymis secretory protein Li 39, HEL-S-39, OI9, Peptidyl-prolyl cis-trans isomerase B, peptidylprolyl isomerase B, peptidylprolyl isomerase B (cyclophilin B), PPIase, PPIase B, Ppib, Rotamase, Rotamase B, S-cyclophilin, S-cyclophylin, SCYLP
Gene Symbols PPIB
Host Species Rabbit
Immunogen Synthetic peptide within Human Cyclophilin B aa 171-215
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19035, 5479, 64367
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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