Invitrogen™ CYFIP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100463

Catalog No. PIPA5100463

Description

Antibody detects endogenous levels of total CYFIP2.

CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.

Specifications

• Antigen: CYFIP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYFIP2
• Gene Alias: 1500004I01Rik; 6430511D02Rik; AA930218; AU022376; cyfip2; cytoplasmic FMR1 interacting protein 2; cytoplasmic FMR1-interacting protein 2; Kiaa1168; mKIAA1168; p53-inducible protein 121; PIR121
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26999, 76884
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q5SQX6, Q96F07
• Gene Symbols: CYFIP2
• Immunogen: A synthesized peptide derived from human CYFIP2(Accession Q96F07), corresponding to amino acid residues K503-P553.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Monkey
• Product Type: Antibody
• Isotype: IgG