Invitrogen™ CYP11A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109610

Catalog No. PIPA5109610

Description

Immunogen sequence: ISTRSPRPFN EIPSPGDNGW LNLYHFWRET GTHKVHLHHV QNFQKYGPIY REKLGNVESV YVIDPEDVAL LFKSEGPNPE RFLIPPWVAY HQYYQRPIGV LLKKSAAWKK DRVALNQEVM APEATKNFLP LLDAVSRDFV SVLHRRIKKA GSGNYSGDIS DDLFRFAFES ITNVIFGERQ GMLEEVVNPE AQRFIDAIYQ MFHTSVPMLN LPPDLFRLFR TKTWKDHVAA WDVIFSKADI YTQNFYWELR QKGSVHHDYR GILYRLLGDS KMSFEDIKAN V.

CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc and cytochrome P450, subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under the modulation of cAMP signal. CYP11A1 in steroidogenic cells converts cholesterol to pregnenolone, which is determined by hormonal control of cholesterol availability. Expression of the CYP11A1 gene is controlled by the transcription factor SF-1, and the upstream SF-1 binding site in the CYP11A1 gene is required for hormonal stimulation. c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression. Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in the interstitial cell monolayer, which has a fully functional adenylate cyclase.

Specifications

• Antigen: CYP11A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYP11A1
• Gene Alias: cholesterol 20-22 desmolase; cholesterol desmolase; cholesterol monooxygenase (side-chain cleaving); cholesterol side chain cleavage; cholesterol side-chain cleavage cytochrome P450; cholesterol side-chain cleavage enzyme, mitochondrial; cscc; Cyp11a; Cyp11a1; Cyp11a-1; CYPXIA1; cytochrome P450 11a cholesterol side chain cleavage; cytochrome P450 11A1; cytochrome P450 family 11 subfamily A member 1; cytochrome P450 family 11 subfamily A polypeptide 1; cytochrome P450 side-chain cleavage enzyme; cytochrome P450 subfamily 11A; cytochrome P450(scc); cytochrome P450, 11a, cholesterol side-chain cleavage; cytochrome P450, family 11, subfamily A, polypeptide 1; cytochrome P450, subfamily XIA (cholesterol side chain cleavage); cytochrome P450C11A1; D9Ertd411e; P450(scc); P450scc; Scc; steroid 20-22-lyase
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13070, 1583, 29680
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P05108, P14137, Q9QZ82
• Gene Symbols: CYP11A1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 40-320 of human CYP11A1 (NP_0007722).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG