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Invitrogen™ CYP11B1 Polyclonal Antibody
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Catalog No. PIPA545063
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100 μL
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PIPA545063 100 μL
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Catalog No. PIPA545063 Supplier Invitrogen™ Supplier No. PA545063
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Description

Rabbit Polyclonal Antibody

Peptide sequence: ARNPNVQQAL RQESLAAAAS ISEHPQKATT ELPLLRAALK ETLRLYPVGL Sequence homology: Human: 100%; Pig: 79%; Sheep: 79%.

The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CYP11B1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene CYP11B1
Gene Accession No. P15538
Gene Alias 11-beta-hydroxylase; AA389061; aldosterone synthase; Cp11ba; CPN1; CYP11B; CYP11B1; Cyp11b-1; CYPXIB1; Cytochrome P450 11B1, mitochondrial; cytochrome P450 family 11 subfamily B member 1; cytochrome p450 XIB1; cytochrome P450(11 beta)-DS; cytochrome P450, family 11, subfamily b, polypeptide 1; cytochrome P450, subfamily 11B, polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); cytochrome P450C11; cytochrome P-450c11; DKFZp686B05283; FHI; FLJ36771; P450(11 beta)-DS; P450C 11; P450C11; RATCP11BA; S11BH; steroid 11-beta-hydroxylase; steroid 11-beta-hydroxylase, CYP11B1; steroid 11-beta-monooxygenase; steroid-11-beta-hydroxylase
Gene Symbols CYP11B1
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal of human CYP11B1 (aa 331-380).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1584
Target Species Human, Monkey
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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