Invitrogen™ CYP11B1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563290

Catalog No. PIPA563290

Description

Immunogen sequence: RFLPMVDAVA RDFSQALKKK VLQNARGSLT LDVQPSIFHY TIEASNLALF GERLGLVGHS PSSASLNFLH ALEVMFKSTV QLMFMPR Highest antigen sequence identity to the following orthologs: Mouse - 71%, Rat - 72%.

The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.

Specifications

• Antigen: CYP11B1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYP11B1
• Gene Alias: 11-beta-hydroxylase; AA389061; aldosterone synthase; Cp11ba; CPN1; CYP11B; CYP11B1; Cyp11b-1; CYPXIB1; Cytochrome P450 11B1, mitochondrial; cytochrome P450 family 11 subfamily B member 1; cytochrome p450 XIB1; cytochrome P450(11 beta)-DS; cytochrome P450, family 11, subfamily b, polypeptide 1; cytochrome P450, subfamily 11B, polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); cytochrome P450C11; cytochrome P-450c11; DKFZp686B05283; FHI; FLJ36771; P450(11 beta)-DS; P450C 11; P450C11; RATCP11BA; S11BH; steroid 11-beta-hydroxylase; steroid 11-beta-hydroxylase, CYP11B1; steroid 11-beta-monooxygenase; steroid-11-beta-hydroxylase
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1584
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P15538
• Gene Symbols: CYP11B1
• Immunogen: Recombinant protein corresponding to Human CYP11B1. Recombinant protein control fragment (Product #RP-104168).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG