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CYP11B1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985736
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50-198-5736 100 μL
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Catalog No. 50-198-5736 Supplier Bioss Supplier No. BS3898R
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Description

Rabbit Polyclonal Antibody

The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.

Specifications

Antigen CYP11B1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene CYP11B1
Gene Accession No. P15538
Gene Alias 11-beta-hydroxylase; CPN1; CYP11B; CYP11B1; CYPXIB1; Cytochrome P450 11B1, mitochondrial; cytochrome P450 family 11 subfamily B member 1; cytochrome p450 XIB1; cytochrome P450, family 11, subfamily B, polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; Cytochrome P450C11; Cytochrome P-450c11; DKFZp686B05283; FHI; FLJ36771; P450C 11; P450C11; S11BH; steroid 11-beta-hydroxylase; Steroid 11-beta-hydroxylase, CYP11B1; steroid 11-beta-monooxygenase
Gene Symbols CYP11B1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human CYP11B1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1584
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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