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Invitrogen™ CYP17A1 Polyclonal Antibody
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Catalog No. PIPA5120237
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PIPA5120237 100 μL
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Catalog No. PIPA5120237 Supplier Invitrogen™ Supplier No. PA5120237
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Description

Rabbit Polyclonal Antibody

Positive test controls include: Rat testis. The target is usually found in the following locations: Membrane. Immunogen sequence: LSKDSLVDLV PWLKIFPNKT LEKLKSHVKI RNDLLNKILE NYKEKFRSDS ITNMLDTLMQ AKMNSDNGNA GPDQDSELLS DNHILTTIGD IFGAGVETTT SVVKWTLAFL LHNPQVKKKL YEEIDQNVGF SRTPTISDRN RLLLLEATIR EVLRLRPVAP MLIPHKANVD SSIGEFAVDK GTEVIINLWA LHHNEKEWHQ PDQFMPERFL NPAGTQLISP SVSYLPFGAG PRSCIGEILA RQELFLIMAW LLQRFDLEVP DDGQLPSLEG IPKVVFLIDS FKVKIKVRQA WREAQAEGST.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CYP17A1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.49 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CYP17A1
Gene Accession No. P05093, P11715, P27786
Gene Alias 17a-hydroxylase; 17-alpha-hydroxyprogesterone aldolase; CPT7; Cyp17; Cyp17a1; CYPXVII; cytochrome P450 17A1; cytochrome P450 family 17 subfamily A member 1; cytochrome p450 XVIIA1; cytochrome P450, 17; cytochrome P450, 17a1; cytochrome P450, family 17, subfamily A, polypeptide 1; cytochrome P450, subfamily 17; Cytochrome P450, subfamily XVII; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia; Cytochrome P450c17; cytochrome P450-C17; HGNC:2593; P45017alpha; p450c17; P450-C17; S17AH; steroid 17-alpha hydroxylase; steroid 17-alpha-hydroxylase/17,20 lyase; Steroid 17-alpha-monooxygenase
Gene Symbols CYP17A1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human CYP17A1 (NP_000093.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13074, 1586, 25146
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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