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Invitrogen™ CYP1A2 Polyclonal Antibody
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Catalog No. PA1341
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100 μL
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PA1341 100 μL
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Catalog No. PA1341 Supplier Invitrogen™ Supplier No. PA1341
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Description

Rabbit Polyclonal Antibody

PA1-341 detects cytochrome P450 (P450) 1A2 from human cells as well as recombinant human P450 1A2. This antibody detects, to a lesser extent, other P450 isoforms. PA1-341 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~56 kDa protein representing recombinant human P450 1A2. The PA1-341 immunogen is purified, His-tagged, full length human P450 1A2 fusion protein.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CYP1A2
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene Cyp1a2
Gene Accession No. P05177
Gene Alias aromatic compound inducible; aryl hydrocarbon hydroxylase; cholesterol 25-hydroxylase; CP12; CYP; Cyp1a1; Cyp1a2; Cyp1a-2; CYPD45; CYPIA2; Cytochrome P(3)450; cytochrome P-448; cytochrome P450 1A2; Cytochrome P450 4; cytochrome P450 family 1 subfamily A member 2; cytochrome P450 family 1 subfamily a polypeptide 1; Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d); cytochrome P450, 1a2; cytochrome P450, 1a2, aromatic compound inducible; cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d); cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; Cytochrome P-450d; cytochrome P450-D; Cytochrome P450-P2; cytochrome P450-P3; dioxin-inducible P3-450; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P(3)450; P3-450; P-448; P450; P450 4; P450 form 4; P450(PA); P450-3; P-450d; P450-D; P450-P3; RATCYPD45; xenobiotic monooxygenase
Gene Symbols Cyp1a2
Host Species Rabbit
Immunogen Purified, His-tagged, full length human P450 1A2 fusion protein.
Purification Method Ammonium sulfate precipitation
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1544
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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