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Invitrogen™ CYP27A1 Polyclonal Antibody
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Catalog No. PIPA596021
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100 μL
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PIPA596021 100 μL
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Catalog No. PIPA596021 Supplier Invitrogen™ Supplier No. PA596021
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: NQVSDMAQLF YYFALEAICY ILFEKRIGCL QRSIPEDTVT FVRSIGLMFQ NSLYATFLPK WTRPVLPFWK RYLDGWNAIF SFGKKLIDEK LEDMEAQLQA AGPDGIQVSG YLHFLLASGQ LSPREAMGSL PELLMAGVDT TSNTLTWALY HLSKDPEIQE ALHEEVVGVV PAGQVPQHKD FAHMPLLKAV LKETLRLYPV V; Positive Samples: 293T, Mouse kidney, Rat liver; Cellular Location: Mitochondrion membrane.

CYP27A1 participates in the degradation of cholesterol to bile acids in both the classic and acidic pathways. [1] It is the initiating enzyme in the acidic pathway to bile acids, yielding oxysterols by introducing a hydroxyl group to the carbon at the 27 position in cholesterol. In the acidic pathway, it produces 27-hydroxycholesterol from cholesterol whereas in the classic or neutral pathway, it produces 3beta-hydroxy-5-cholestenoic acid. It is also involved in the metabolism of vitamin D3. While CYP27A1 is present in many different tissues, its function in these tissues is largely uncharacterized. In macrophages, 27-hydroxycholesterol generated by this enzyme may be helpful against the production of inflammatory factors associated with cardiovascular disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CYP27A1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.98 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene CYP27A1
Gene Accession No. P17178, Q02318, Q9DBG1
Gene Alias 1300013A03Rik; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; cholestanetriol 26-monooxygenase; cholesterol 27 hydroxylase; CP27; CTX; CYP27; CYP27A1; cyt; cytochrome P450 27; cytochrome P450 family 27 subfamily A member 1; cytochrome P450, 27; cytochrome P450, 27a1; cytochrome P450, family 27, subfamily a, polypeptide 1; cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1; Cytochrome P-450C27/25; P450C27; Sterol 26-hydroxylase, mitochondrial; sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase
Gene Symbols CYP27A1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 200-400 of human CYP27A1 (NP_0007751).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 104086, 1593, 301517
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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