Invitrogen™ CYP2A6/CYP2A7/CYP2A13 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599833

Catalog No. PIPA599833

Description

Antibody detects endogenous levels of total Cytochrome P450 2A6/7/13.

The cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.

Specifications

• Antigen: CYP2A6/CYP2A7/CYP2A13
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYP2A6
• Gene Alias: 1,4-cineole 2-exo-monooxygenase; Coumarin 7-hydroxylase; CPA6; CPA7; CPAD; CYP2A; CYP2A13; CYP2A3; CYP2A6; CYP2A7; CYPIIA13; CYPIIA6; CYPIIA7; Cytochrome P450 2A13; cytochrome P450 2A6; Cytochrome P450 2A7; cytochrome P450 family 2 subfamily A member 13; cytochrome P450 family 2 subfamily A member 6; cytochrome P450 family 2 subfamily A member 7; cytochrome P450 IIA3; Cytochrome P450 IIA4; cytochrome P450(I); cytochrome P450, family 2, subfamily A, polypeptide 13; cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450, family 2, subfamily A, polypeptide 7; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; cytochrome P450IIA4; flavoprotein-linked monooxygenase; P450C2A; P450-IIA4; P450PB; xenobiotic monooxygenase
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1548, 1549, 1553
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P11509, P20853, Q16696
• Gene Symbols: CYP2A13, CYP2A6, CYP2A7
• Immunogen: A synthesized peptide derived from human CYP2A6(Accession P11509), corresponding to amino acid residues S4-M54.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG