CYP2D6 Mouse anti-Human, Clone: 8B11D12, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 602971IG150UL

Catalog No. 50-173-6392

Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme′s substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: CYP2D6
• Classification: Monoclonal
• Concentration: 1.85 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P10635
• Gene Symbols: CYP2D6
• Immunogen: CYP2D6 Fusion Protein Ag12605
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: 8B11D12
• Conjugate: Unconjugated
• Gene: CYP2D6
• Gene Alias: CPD6, CYP2D, CYP2D6, CYP2DL1, Cytochrome P450 2D6, P450 DB1, P450C2D, P450DB1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1565
• Content And Storage: -20°C
• Form: Liquid