Invitrogen™ CYP2E1 Monoclonal Antibody (2C7G1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549163

Catalog No. PIMA549163

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human HCCP tissue, rat liver tissue, mouse liver tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Specifications

• Antigen: CYP2E1
• Classification: Monoclonal
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and no preservative
• Gene Accession No.: P05181, P05182, Q05421
• Gene Symbols: Cyp2e1
• Immunogen: E.coli-derived human Cytochrome P450 2E1/CYP2E1 recombinant protein (Position: H355-S493).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: 2C7G1
• Conjugate: Unconjugated
• Gene: Cyp2e1
• Gene Alias: 4-nitrophenol 2-hydroxylase; CP2E1; CPE1; Cyp2e; Cyp2e1; Cyp2e-1; CYPIIE1; cytochrome P450 2E1; cytochrome P450 family 2 subfamily E member 1; cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, 2e1, ethanol inducible; cytochrome P450, family 2, subfamily e, polypeptide 1; cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; cytochrome P450-ALC; Cytochrome P450-J; cytochrome P450RLM6; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450C2E; P450-J; P450RLM6; xenobiotic monooxygenase
• Host Species: Mouse
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13106, 1571, 25086
• Content And Storage: -20°C
• Form: Lyophilized