Invitrogen™ CYP3A7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120066

Catalog No. PIPA5120066

Description

Positive test controls include: A-549, HT-29, Mouse liver, Mouse lung, Rat liver. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein. Immunogen sequence: KVISFLTKSV KQIKEGRLKE TQKHRVDFLQ LMIDSQNSKD SETHKALSDL ELMAQSIIFI FAGYETTSSV LSFIIYELAT HPDVQQKVQK EIDTVLPNKA PPTYDTVLQL EYLDMVVNET LRLFPVAMRL ERVCKKDVEI NGMFIPKGVV VMIPSYVLHH DPKYWTEPEK FLPERFSKKN KDNIDPYIYT PFGSGPRNCI GMRFALVNMK LALVRVLQNF SFKPCKETQI PLKLRFGGLL LTEKPIVLKA ESRDETVSGA.

This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.

Specifications

• Antigen: CYP3A7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYP3A7
• Gene Alias: aryl hydrocarbon hydroxylase; CP37; CYP3A7; CYPIIIA7; Cytochrome P450 3A7; cytochrome P450 family 3 subfamily A member 7; cytochrome P450, family 3, subfamily A, polypeptide 7; cytochrome P450, subfamily IIIA, polypeptide 7; cytochrome P450-HFLA; flavoprotein-linked monooxygenase; microsomal monooxygenase; P-450(HFL33); P-450111A7; P450-HFLA; P450HLp2; xenobiotic monooxygenase
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1551
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.94 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P24462
• Gene Symbols: CYP3A7
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A7 (NP_000756.3).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG