Invitrogen™ CYP46A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121211

Catalog No. PIPA5121211

Description

Positive test controls include: U-87MG, U-251MG, MCF7, Mouse liver, Mouse brain, Rat liver. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome membrane, Single-pass membrane protein. Immunogen sequence: HRARSRYEHI PGPPRPSFLL GHLPCFWKKD EVGGRVLQDV FLDWAKKYGP VVRVNVFHKT SVIVTSPESV KKFLMSTKYN KDSKMYRALQ TVFGERLFGQ GLVSECNYER WHKQRRVIDL AFSRSSLVSL METFNEKAEQ LVEILEAKAD GQTPVSMQDM LTYTAMDILA KAAFGMETSM LLGAQKPLSQ AVKLMLEGIT ASRNTLAKFL PGKRKQLREV RESIRFLRQV GRDWVQRRRE ALKRGEEVPA DILTQIL.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

Specifications

• Antigen: CYP46A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYP46A1
• Gene Alias: CH24H; Cholesterol 24-hydroxylase; Cholesterol 24-monooxygenase; Cholesterol 24S-hydroxylase; cholestrol 24-hydroxylase; CP46; CYP46; CYP46A1; Cytochrome P450 46A1; cytochrome P450 family 46 subfamily A member 1; cytochrome P450, 46 (cholesterol 24-hydroxylase); cytochrome P450, 46a1 (cholesterol 24-hydroxylase); cytochrome P450, family 46, subfamily A, polypeptide 1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10858, 13116, 362782
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.9 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9WVK8, Q9Y6A2
• Gene Symbols: CYP46A1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-280 of human CYP46A1 (NP_006659.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG