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Invitrogen™ CYP46A1 Polyclonal Antibody
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Catalog No. PIPA5121211
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PIPA5121211 100 μL
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Catalog No. PIPA5121211 Supplier Invitrogen™ Supplier No. PA5121211
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Description

Rabbit Polyclonal Antibody

Positive test controls include: U-87MG, U-251MG, MCF7, Mouse liver, Mouse brain, Rat liver. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome membrane, Single-pass membrane protein. Immunogen sequence: HRARSRYEHI PGPPRPSFLL GHLPCFWKKD EVGGRVLQDV FLDWAKKYGP VVRVNVFHKT SVIVTSPESV KKFLMSTKYN KDSKMYRALQ TVFGERLFGQ GLVSECNYER WHKQRRVIDL AFSRSSLVSL METFNEKAEQ LVEILEAKAD GQTPVSMQDM LTYTAMDILA KAAFGMETSM LLGAQKPLSQ AVKLMLEGIT ASRNTLAKFL PGKRKQLREV RESIRFLRQV GRDWVQRRRE ALKRGEEVPA DILTQIL.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CYP46A1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.9 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CYP46A1
Gene Accession No. Q9WVK8, Q9Y6A2
Gene Alias CH24H; Cholesterol 24-hydroxylase; Cholesterol 24-monooxygenase; Cholesterol 24S-hydroxylase; cholestrol 24-hydroxylase; CP46; CYP46; CYP46A1; Cytochrome P450 46A1; cytochrome P450 family 46 subfamily A member 1; cytochrome P450, 46 (cholesterol 24-hydroxylase); cytochrome P450, 46a1 (cholesterol 24-hydroxylase); cytochrome P450, family 46, subfamily A, polypeptide 1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Gene Symbols CYP46A1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 24-280 of human CYP46A1 (NP_006659.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10858, 13116, 362782
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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