Invitrogen™ CYP4F2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553117

Catalog No. PIPA553117

Description

Immunogen sequence: RRNWFWGHQG MVNPTEEGMR VLTQLVATYP QGFKVWMGPI SPLLSLCHPD Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 70%.

CYP4F isoforms are involved in the oxidation of important cellular mediators, such as leukotriene B4 (LTB4) and prostaglandins. CYP4F2 catalyzes omega-hydroxylation of LTB4 to a less potent proinflammatory eicosanoid, 20-OH-LTB4 as well as arachidonic acid. CYP4F2 is expressed in liver and kidney. Its expression is repressed by peroxisomal proliferators and induced by retinoic acid. X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder biochemically characterized by elevated levels of very long-chain fatty acids (VLCFA). CYP4F2 participates in the omega-hydroxylation of VLCFAs, which may provide an alternative mode of treatment for X-ALD patients.

Specifications

• Antigen: CYP4F2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYP4F2
• Gene Alias: 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; Arachidonic acid omega-hydroxylase; CPF2; CYP4F2; CYPIVF2; cytochrome P450 4F2; cytochrome P450 family 4 subfamily F member 2; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; cytochrome P450-LTB-omega; Docosahexaenoic acid omega-hydroxylase; docosahexaenoic acid omega-hydroxylase CYP4F3; phylloquinone omega-hydroxylase CYP4F2; leukotriene-B(4) 20-monooxygenase 1; Leukotriene-B(4) omega-hydroxylase 1; phylloquinone omega-hydroxylase CYP4F2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8529
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P78329
• Gene Symbols: CYP4F2
• Immunogen: Recombinant protein corresponding to Human CYP4F2. Recombinant protein control fragment (Product #RP-90565).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG