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Invitrogen™ CYP4F2 Polyclonal Antibody
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Catalog No. PIPA527769
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100 μL
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PIPA527769 100 μL
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Catalog No. PIPA527769 Supplier Invitrogen™ Supplier No. PA527769
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HeLa, HeLa membrane. Predicted reactivity: Bovine (87%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CYP4F isoforms are involved in the oxidation of important cellular mediators, such as leukotriene B4 (LTB4) and prostaglandins. CYP4F2 catalyzes omega-hydroxylation of LTB4 to a less potent proinflammatory eicosanoid, 20-OH-LTB4 as well as arachidonic acid. CYP4F2 is expressed in liver and kidney. Its expression is repressed by peroxisomal proliferators and induced by retinoic acid. X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder biochemically characterized by elevated levels of very long-chain fatty acids (VLCFA). CYP4F2 participates in the omega-hydroxylation of VLCFAs, which may provide an alternative mode of treatment for X-ALD patients.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CYP4F2
Applications Western Blot
Classification Polyclonal
Concentration 0.27 mg/mL
Conjugate Unconjugated
Formulation PBS with 10% glycerol and 0.01% thimerosal; pH 7
Gene CYP4F2
Gene Accession No. P78329
Gene Alias 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; Arachidonic acid omega-hydroxylase; CPF2; CYP4F2; CYPIVF2; cytochrome P450 4F2; cytochrome P450 family 4 subfamily F member 2; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; cytochrome P450-LTB-omega; Docosahexaenoic acid omega-hydroxylase; docosahexaenoic acid omega-hydroxylase CYP4F3; phylloquinone omega-hydroxylase CYP4F2; leukotriene-B(4) 20-monooxygenase 1; Leukotriene-B(4) omega-hydroxylase 1; phylloquinone omega-hydroxylase CYP4F2
Gene Symbols CYP4F2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Cytochrome P450 4F2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100113470, 8529
Target Species Human, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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