Invitrogen™ CYP4F3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA542066

Catalog No. PIPA542066

Description

Peptide sequence: LAWTYTFYDN CCRLRCFPQP PKRNWFLGHL GLIHSSEEGL LYTQSLACTF Sequence homology: Dog: 86%; Human: 100%; Mouse: 85%; Rat: 85%.

Cytochrome P450 super family proteins are monooxygenases which catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids and lipids. CYP4F3, a 60 kDa protein, is a novel member of this family. It consists of a conserved heme-binding domain near the C-terminus and catalyzes the u-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation. CYP4F3 exists in two functionally distinct isoforms: CYP4F3A, a neutrophil isoform, is particularly expressed in neutrophils and myeloid cells and catalyzes the microsomal u-hydroxylation of LTB4. It interacts with CD11b and myeloperoxidase on myeloid cells and regulates cellular development in bone marrow. CYP4F3B, a liver isoform, catalyzes the conversion of arachidonic acid to 20-HETE, a potent activator of PKC. Its role has been implicated in cell proliferation, vascular tone and natriuresis.

Specifications

• Antigen: CYP4F3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYP4F3
• Gene Alias: 1810054N16Rik; 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; CPF3; CYP4F; Cyp4f18; CYP4F3; Cypf18; CYPIVF3; cytochrome P-450; cytochrome P450 4F3; cytochrome P450 CYP4F18; cytochrome P450 family 4 subfamily F member 3; cytochrome P450, 4f18; cytochrome P450, family 4, subfamily f, polypeptide 18; cytochrome P450, family 4, subfamily F, polypeptide 3; cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase); cytochrome P450-LTB-omega; Docosahexaenoic acid omega-hydroxylase CYP4F3; leukotriene B4 omega hydroxylase; leukotriene-B(4) 20-monooxygenase 2; Leukotriene-B(4) omega-1/omega-2 hydroxylase; Leukotriene-B(4) omega-hydroxylase 2; leukotriene-B4 20-monooxygenase; LTB4H
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4051
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q08477
• Gene Symbols: CYP4F3
• Immunogen: Synthetic peptide directed towards the N-terminal of human CYP4F3 (aa 35-84).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG