Invitrogen™ CYP4F3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103397

Catalog No. PIPA5103397

Description

Antibody detects endogenous levels of total Cytochrome P450 4F3.

Cytochrome P450 super family proteins are monooxygenases which catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids and lipids. CYP4F3, a 60 kDa protein, is a novel member of this family. It consists of a conserved heme-binding domain near the C-terminus and catalyzes the u-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation. CYP4F3 exists in two functionally distinct isoforms: CYP4F3A, a neutrophil isoform, is particularly expressed in neutrophils and myeloid cells and catalyzes the microsomal u-hydroxylation of LTB4. It interacts with CD11b and myeloperoxidase on myeloid cells and regulates cellular development in bone marrow. CYP4F3B, a liver isoform, catalyzes the conversion of arachidonic acid to 20-HETE, a potent activator of PKC. Its role has been implicated in cell proliferation, vascular tone and natriuresis.

Specifications

• Antigen: CYP4F3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYP4F3
• Gene Alias: 1810054N16Rik; 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; CPF3; CYP4F; Cyp4f18; CYP4F3; Cypf18; CYPIVF3; cytochrome P-450; cytochrome P450 4F3; cytochrome P450 CYP4F18; cytochrome P450 family 4 subfamily F member 3; cytochrome P450, 4f18; cytochrome P450, family 4, subfamily f, polypeptide 18; cytochrome P450, family 4, subfamily F, polypeptide 3; cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase); cytochrome P450-LTB-omega; Docosahexaenoic acid omega-hydroxylase CYP4F3; leukotriene B4 omega hydroxylase; leukotriene-B(4) 20-monooxygenase 2; Leukotriene-B(4) omega-1/omega-2 hydroxylase; Leukotriene-B(4) omega-hydroxylase 2; leukotriene-B4 20-monooxygenase; LTB4H
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4051
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q08477
• Gene Symbols: CYP4F3
• Immunogen: A synthesized peptide derived from human CYP4F3(Accession Q08477), corresponding to amino acid residues G65-A115.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov