Invitrogen™ CYP51A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560395

Catalog No. PIPA560395

Description

Immunogen sequence: AIAFGKSPIE FLENAYEKYG PVFSFTMVGK TFTYLLGSDA AALLFNSKNE DLNAEDVYSR LTTPVFGKGV AYDVPNPVFL EQKKML Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 95%.

P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. Several P450 enzymes have been classified by sequence similarities as members of the CYP1A and CYP2A subfamilies. CYP51A1 (cytochrome P450, family 51, subfamily A, polypeptide 1), also known as LDM (lanosterol 14-alpha demethylase) or cytochrome P450-14DM, is a 503 amino acid protein localized to endoplasmic reticulum membrane. CYP51A1 is an important enzyme for zymosterol and steroid biosynthesis. CYP51A1 catalyzes C14-demethylation of lanosterol, transforming lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. CYP51A1 is ubiquitously expressed, with highest levels found in liver, ovary, testis, lung, kidney and prostate.

Specifications

• Antigen: CYP51A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYP51A1
• Gene Alias: AI426508; CP51; CYP51; CYP51A1; CYPL1; CYPLI; Cytochrom P450 Lanosterol 14 alpha-demethylase; Cytochrome P450 51; cytochrome P450 51A1; cytochrome P450 family 51 subfamily A member 1; cytochrome P450 Lanosterol 14 alpha-demethylase; cytochrome P450, 51; cytochrome P450, 51 (lanosterol 14-alpha-demethylase); cytochrome P450, family 51; cytochrome P450, family 51, subfamily A, polypeptide 1; cytochrome P450, subfamily 51; Cytochrome P45014DM; cytochrome P450-14DM; cytochrome P450LI; Lanosterol 14-alpha demethylase; lanosterol 14-alpha-demethylase; LDM; P450 14DM; P45014DM; P450-14DM; P450L1; P450LI; RATCP14DM; Sterol 14-alpha demethylase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1595
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q16850
• Gene Symbols: CYP51A1
• Immunogen: Recombinant protein corresponding to Human CYP51A1. Recombinant protein control fragment (Product #RP-98312).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG