Invitrogen™ Cystatin 2 Polyclonal Antibody

Catalog No.	Quantity
PIPA560476	100 μL

Catalog No. PIPA560476 Supplier Invitrogen™ Supplier No. PA560476

Description

Rabbit Polyclonal Antibody

Immunogen sequence: EEDRIIEGGI YDADLNDERV QRALHFVIS Highest antigen sequence identity to the following orthologs: Mouse - 38%, Rat - 38%.

The cystatin superfamily is a well-established family of cysteine protease inhibitors. Cystatins A and B (type 1) are mainly intracellular; cystatins C, D, E/M, F, G, S, SN and SA cystatins are extracellular (type 2); and the kininogens are type 3 cystatins which are intravascular proteins. All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, and some also inhibit legumain family enzymes. Cystatin SA, cystatin S and cystatin SN are found primarily in saliva. Cystatin S and SN can also be expressed in tears, urine and seminal fluid. Cystatin C is a related protein which is expressed in brain, thymus, ovary, epididymis and vas deferens. Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate the inhibition of cathepsin proteins. The fetuins, part of the cystatin superfamily, are secretable proteins that influence osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors and the response to systemic inflammation. High molecular weight kininogen (Kininogen HC) and low molecular weight kininogen (Kininogen LC) have varied roles, though they both inhibit the thrombin- and plasmin-induced aggregation of thrombocytes.

Specifications

• Antigen: Cystatin 2
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: CST2
• Gene Accession No.: P09228
• Gene Alias: CST2; cystatin 2; cystatin S5; cystatin SA; cystatin-2; Cystatin-S5; cystatin-SA; cysteine-proteinase inhibitor; salivary cysteine (thiol) protease inhibitor
• Gene Symbols: CST2
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human Cystatin 2. Recombinant protein control fragment (Product #RP-99581).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1470
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG