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Cytochrome c, Mouse anti-Human,Mouse,Rat,Amphibian,Avian,Canine,Drosophila,Equine, DyLight 594, Clone: SPM389, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP247692DL594

Catalog No. NB007140


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Description

Description

Cytochrome c Monoclonal antibody specifically detects Cytochrome c in Human, Mouse, Rat, Amphibian, Avian, Canine, Drosophila, Equine samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence.
Specifications

Specifications

Cytochrome c
SPM389
Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Conjugated, Purified
CYCS
Synthetic peptides corresponding to amino acid 1-80, 81-104 and 66-104 of pigeon cytochrome c
Protein A or G purified
RUO
Store at 4°C in the dark.
Monoclonal
Amphibian, Avian, Canine, Drosophila, Equine, Human, Mouse, Rat
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
DyLight 594
50mM Sodium Borate with 0.05% Sodium Azide
CYCHCS, cytochrome c, cytochrome c, somatic, THC4
Mouse
IgG2b Kappa
0.1 mL
Apoptosis, Cellular Markers, Cholesterol Metabolism, Core ESC Like Genes, Lipid and Metabolism, Mitochondrial Markers, Stem Cell Markers
Primary
It recognizes an epitope within amino acids 93-104 of pigeon Cytochrome C, a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).
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