MilliporeSigma™ Cytochrome P450 26A1, Mouse, Unlabeled, Clone: F27P6A1,

Catalog No.	Quantity	Conjugate
MABS1319MI	100 μg	Unconjugated

Catalog No. MABS1319MI Supplier MilliporeSigma™ Supplier No. MABS1319

Description

Mouse Monoclonal Antibody

Cytochrome P450 26A1 (UniProt O43174; also known as Cytochrome P450 retinoic acid-inactivating 1, Cytochrome P450RAI, hP450RAI, Retinoic acid 4-hydroxylase, Retinoic acid-metabolizing cytochrome) is encoded by the CYP26A1 (also known as CYP26, P450RAI1) gene (Gene ID 1592) in human. CYP26A1 is a retinoic acid (RA) metabolizing enzyme that is mainly located in the endoplasmic reticulum membranes and is involved in vitamin A metabolism. It can generate several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. RA is a tight binding ligand for CYP26A1 with lownm binding affinity. Higher expression of CYP26A1 is observed in the adult liver, heart, pituitary gland, placenta, and various regions of the brain. CYP26A1 activity is important for the maintenance of pregnancy, especially during the process of blastocyst implantation. Elevated CYP26A1 expression and RA catabolic activity have been detected in breast epithelial adenocarcinoma cells in culture, in leukemic cells from patients with acute promyelocytic leukemia, and in cells derived from squamous cell carcinoma.

Specifications

• Antigen: Cytochrome P450 26A1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: F27P6A1
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Unconjugated
• Formulation: Purified mouse IgG2bκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene: CYP26A1, CYP26, P450RAI1
• Gene Accession No.: O43174
• Host Species: Mouse
• Immunogen: Ovalbumin-conjugated linear peptide corresponding to a sequence near the C-terminus of human cytochrome P450 26A1 (Kumarakulasingham, M., et al. (2005). Clin. Cancer Res. 11(10):3758-3765).
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_000774
• Test Specificity: Target band specificity was confirmed by Western blotting of lysate from cytochrome P450 26A1-overexpressing human embryonic kidney cells (Brown, G.T., et al. (2014). PLoS One. 9(3):e90776).
• Target Species: Human
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Form: Purified
• Isotype: IgG2b κ

For Research Use Only. Not for use in diagnostic procedures.