Cytochrome P450 Polyclonal Antibody, Rockland™

Catalog No.	Quantity
50-199-2148	25 μL
50-199-2147	100 μg

Catalog No. 50-199-2148 Supplier Rockland Immunochemicals Supplier No. 600401HB7S

Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity purified antibody is directed against human cytochrome p450. Blast analysis the immunogen sequence shows 83.3% identity with mouse, rat, hamster, and monkey.

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

Specifications

• Antigen: Cytochrome P450
• Applications: ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene: CYP1A1
• Gene Accession No.: P00185, P04798
• Gene Alias: AHH; AHRR; aromatic compound inducible; aryl hydrocarbon hydroxylase; CP11; CYP; CYP1; CYP1A1; Cyp1a-1; Cyp1a2; Cyp45c; Cypc45c; CYPIA1; cytochrome P1-450; cytochrome P1-450, dioxin-inducible; Cytochrome P450 1A1; cytochrome P450 family 1 subfamily A member 1; cytochrome P450 family 1 subfamily a polypeptide 2; Cytochrome P450 form 6; cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c); cytochrome P450 subfamily I, polypeptide 1; cytochrome P450, 1a1; cytochrome P450, 1a1, aromatic compound inducible; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c); cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; Cytochrome P450-C; Cytochrome P450MT2; Cytochrome P450MT2A; Cytochrome P450MT2B; Cytochrome P450-P1; dioxin-inducible; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P1-4
• Gene Symbols: CYP1A1
• Host Species: Rabbit
• Quantity: 25 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1543, 24296
• Target Species: Human, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid