Invitrogen™ Cytochrome P450 Reductase Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA527328

Catalog No. PIPA527328

Description

Recommended positive controls: HeLa, HepG2, mouse liver. Predicted reactivity: Mouse (90%), Rat (90%), Dog (93%), Pig (87%), Rabbit (88%), Rhesus Monkey (98%), Bovine (93%), Guinea pig (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.

Specifications

• Antigen: Cytochrome P450 Reductase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: POR
• Gene Alias: 4933424M13Rik; CCR; CPR; CY DKFZp686G04235; CYPOR; cytochrome p450 oxidoreductase; cytochrome P450 reductase; DKFZp686G04235; FLJ26468; I79_007261; LOC101115252; NADPH Cytochrome; NADPH-cytochrome P450 oxidoreductase; NADPH-cytochrome P-450 oxidoreductase; NADPH-cytochrome P450 reductase; NADPH--cytochrome P450 reductase; NADPH-cytochrome P-450 reductase; NADPH-dependent cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450 Reductase; P450R; Por; unnamed protein product
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18984, 5447
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.73 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P16435, P37040
• Gene Symbols: POR
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human POR. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG