Invitrogen™ Cytohesin 3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5102870

Catalog No. PIPA5102870

Description

Antibody detects endogenous levels of total CYTH3.

GRP1 (general receptor for phosphoinositides-1) contains a Pleckstrin homology (PH) domain as well as a Sec7 domain. The PH domain has high binding affinity for phosphatidylinositol 3,4,5-trisphosphate Ptdlns(3,4,5)P3), while the Sec7 homology domain is responsible for catalyzing guanine nucleotide exchange of ADP-ribosylation factor (ARF) proteins. GRP1 co-localizes with ARF6 and catalyzes GTP/GDP exchange on ARF6. It is known to interact with Ptdlns(3,4,5)P3 localized to the plasma membrane in vitro and may also be a Ptdlns(3,4,5)P3 receptor. Additionally, GRP1 may regulate protein sorting and membrane trafficking through interaction with the guanosine triphosphate ARF, and may control cell adhesion through interaction with integrins.

Specifications

• Antigen: Cytohesin 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cyth3
• Gene Alias: AI648983; ARF nucleotide-binding site opener 3; ARNO3; CLM3; CYTH3; cytohesin 3; cytohesin-3; General receptor of phosphoinositides 1; GRP1; mSec7-3; PH, SEC7 and coiled-coil domain-containing protein 3; pleckstrin homology, Sec7 and coiled/coil domains 3; pleckstrin homology, Sec7 and coiled-coil domains 3; Protein ARNO3; PSCD3; rSec7-3; Sec7; SEC7 homolog C; Sec7C
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9265
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O43739
• Gene Symbols: Cyth3
• Immunogen: A synthesized peptide derived from human CYTH3(Accession O43739), corresponding to amino acid residues G182-P232.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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