Invitrogen™ Cytokeratin 10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578036

Catalog No. PIPA578036

Description

Positive Control: A431, HeLa, HepG2 Predicted Reactivity: Mouse (89%), Rat (92%), Dog (92%), Bovine (89%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (i.e., skin) and non-keratinizing cells (i.e. mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. At least 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8. 5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification.

Specifications

• Antigen: Cytokeratin 10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KRT10
• Gene Alias: 56 kDa cytokeratin; BCIE; BIE; CK10; CK-10; CK-17; cytokeratin 10; cytokeratin-10; cytokeratin-17; D130054E02Rik; EHK; epidermal keratin 10; epithelial keratin 10; intermediate filament protein; K10; K1C1; Ka10; Ker10; keratin 10; keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris); keratin 10, type I; keratin complex 1, acidic, gene 10; keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 59 kDa; keratin-10; keratin-17; KPP; Krt-1.10; KRT10; krt10 {ECO:0000250; Krt1-10; suprabasal cytokeratin 10; type I keratin KA10; UniProtKB:P13645}
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3858
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.82 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P13645
• Gene Symbols: KRT10
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Cytokeratin 10. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov