Cytokeratin 14/17 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA568451

Catalog No. PIPA568451

Description

Predicted to react with Mouse and Rat samples.

Cytokeratins(CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. Skin) and non-keratinizing cells (ie. Mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different CKs in the molecular range of 40-70 k Da and isoelectric points of 5-805 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.

Specifications

• Antigen: Cytokeratin 14/17
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KRT14
• Gene Alias: 39.1; AI626930; CK14; CK-14; CK-17; cytokeratin 14; cytokeratin-14; Cytokeratin-17; EBS3; EBS4; epidermolysis bullosa simplex, Dowling-Meara, Koebner; K14; K17; Ka14; Ka17; keratin 14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 17; keratin 17, type I; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 17; keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 17; keratin-14; Keratin-17; Krt-1.14; Krt1-14; Krt1-17; KRT14; KRT17; krt17 {ECO:0000250; LOC100737113; NFJ; PC; PC2; PCHC1; type I keratin Ka14; Type I keratin Ka17; UniProtKB:Q04695}
• Host Species: Rabbit
• Purification Method: affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16664, 16667, 287701, 287702, 3861, 3872
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P02533, Q04695, Q61781, Q6IFU8, Q6IFV1, Q9QWL7
• Gene Symbols: KRT14, KRT17
• Immunogen: Synthesized peptide derived from human Cytokeratin 14/17 [aa 261-310].
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov