Invitrogen™ Cytokeratin 14 Monoclonal Antibody (RCK107)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA106323

Catalog No. MA106323

Description

MA1-06323 detects cytokeratin 14 in human, rat, canine, and porcine samples. MA1-06323 has sucessfully been used in Western blotting, immunocytochemistry and immunohistochemistry. The MA1-06323 immunogen is a cytoskeletal preparation of TR146 epithelial cells. Store at 4ºC or in small aliquots at -20ºC.

Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. skin) and non-keratinizing cells (ie. mesothelial cells). At least 20 different CKs can be identified. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). Belonging to the type I subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.

Specifications

• Antigen: Cytokeratin 14
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P02533, Q6IFV1
• Gene Symbols: KRT14, LOC100737113
• Immunogen: Cytoskeletal preparation of TR146 epithelial cells.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat, Canine, Pig
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Clone: RCK107
• Conjugate: Unconjugated
• Gene: KRT14
• Gene Alias: AI626930; CK14; CK-14; cytokeratin 14; cytokeratin-14; EBS3; EBS4; epidermolysis bullosa simplex, Dowling-Meara, Koebner; K14; Ka14; keratin 14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin complex 1, acidic, gene 14; keratin, type I cytoskeletal 14; keratin, type I cytoskeletal 17; keratin-14; Koebner; Krt-1.14; Krt1-14; KRT14; LOC100737113; NFJ; Type I keratin Ka14
• Host Species: Mouse
• Purification Method: purified
• Regulatory Status: RUO
• Gene ID (Entrez): 100685323, 100737113, 287701, 3861
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid