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Invitrogen™ Cytokeratin 14 Monoclonal Antibody (SP53)
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Catalog No. PIMA516370
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500 μL
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PIMA516370 500 μL
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Catalog No. PIMA516370 Supplier Invitrogen™ Supplier No. MA516370
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Description

Rabbit Monoclonal Antibody

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is skin, squamous cell carcinoma or prostate tissue.

Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. skin) and non-keratinizing cells (ie. mesothelial cells). At least 20 different CKs can be identified. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). Belonging to the type I subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cytokeratin 14
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone SP53
Concentration 1.17 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.1% sodium azide; pH 7.6
Gene KRT14
Gene Accession No. P02533, Q61781, Q6IFV1
Gene Alias AI626930; CK14; CK-14; cytokeratin 14; cytokeratin-14; EBS3; EBS4; epidermolysis bullosa simplex, Dowling-Meara, Koebner; K14; Ka14; keratin 14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin complex 1, acidic, gene 14; keratin, type I cytoskeletal 14; keratin, type I cytoskeletal 17; keratin-14; Koebner; Krt-1.14; Krt1-14; KRT14; LOC100737113; NFJ; Type I keratin Ka14
Gene Symbols KRT14
Host Species Rabbit
Immunogen Synthetic peptide corresponding to C-terminus of human keratin 14 protein.
Purification Method Protein A/G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16664, 287701, 3861
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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