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Epredia™ Lab Vision™ Cytokeratin 16 Ab-1, Mouse Monoclonal Antibody

Catalog No. MS620R1 Shop All Epredia Products
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MS620R1 1 mL
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Description

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Epredia™ Cytokeratin 16 Ab-1, Mouse Monoclonal Antibody.

Keratins 6 and 16 are expressed in keratinocytes that are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating.

Host Species: Mouse

Clone: LL025

Isotype: IgG1

Species Reactivity: Human. Does not react with rat. Others not known.

Epitope: C-terminal

Immunogen: A synthetic peptide from the C-terminus of human cytokeratin 16

Molecular Weight: 48 kDa

Positive Control: Squamous cell CA

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO

Specifications

Antigen Cytokeratin 16 Ab-1
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone LL025
Conjugate Unconjugated
Formulation Ready-to-use for IHC (UVLP)
Host Species Mouse
Immunogen A synthetic peptide from the C-terminus of human cytokeratin 16
Quantity 1 mL
Regulatory Status RUO
Research Discipline Cytoskeletal Protein
Primary or Secondary Primary
Target Species Human
Form Prediluted
Isotype IgG1
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