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Cytokeratin 17 Antibody (SPM560), PE, Novus Biologicals™
SDP

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Description

Mouse Monoclonal Antibody

Cytokeratin 17 Monoclonal specifically detects Cytokeratin 17 in Human, Rat, Porcine, Bovine, Goat samples. It is validated for Flow Cytometry.

Specifications

Antigen Cytokeratin 17
Applications Flow Cytometry
Classification Monoclonal
Clone SPM560
Conjugate PE
Dilution Flow Cytometry
Gene Alias 39.1, CK-17, cytokeratin-17, K17, keratin 17, keratin, type I cytoskeletal 17, keratin-17, PC, PC2, PCHC1
Gene Symbols KRT17
Host Species Mouse
Immunogen The cytoskeletal fraction of rat colon epithelium
Molecular Weight of Antigen 46 kDa
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Cancer
Primary or Secondary Primary
Gene ID (Entrez) 3872
Test Specificity Cytokeratin 17 (CK17) is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. CK17 is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as 'epithelial stem cell' marker because CK17 Ab marks basal cell differentiation. CK17 can be useful when included in a panel of antibodies against TTF-1, napsin A, CK56, p63, and SOX-2 for diagnostic differentiation between lung adenocarcinoma (LADC) and lung squamous cell carcinoma (SCLC), especially for poorly-differentiated lung carcinoma. CK17 is expressed in SCLC much higher than in LADC. In breast carcinomas, approximately 20% of patients show no expression of ER, PR and Her2, which are defined as triple negative tumor. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.
Target Species Human, Rat, Pig, Bovine, Goat
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG2b κ
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