Invitrogen™ Cytokeratin 17 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596083

Catalog No. PIPA596083

Description

Immunogen sequence: QYYRTIEELQ NKILTATVDN ANILLQIDNA RLAADDFRTK FETEQALRLS VEADINGLRR VLDELTLARA DLEMQIENLK EELAYLKKNH EEEMNALRGQ VGGEINVEMD AAPGVDLSRI LNEMRDQYEK MAEKNRKDAE DWFFSKTEEL NREVATNSEL VQSGKSEISE LRRTMQALEI ELQSQLSMKA SLEGNLAETE NRYCVQLSQI QGLIGSVEEQ LAQLRCEMEQ QNQEYKILLD VKTRLEQEIA TYRRLLEGED AHLTQYKKEP VTTRQVRTIV EEVQDGKVIS SREQVHQTTR; Positive Samples: HeLa, HepG2, OVCAR3; Cellular Location: Cytoplasm.

Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between approximately40 kDa and approximately68 kDa and isoelectric pH between 4. 9 - 7. 8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Specifications

• Antigen: Cytokeratin 17
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KRT17
• Gene Alias: 39.1; CK17; CK-17; cytokeratin-17; hard keratin; K17; Ka17; keratin 17; keratin 17, type I; keratin complex 1, acidic, gene 17; keratin, type I cytoskeletal 17; Keratin-17; Krt1-17; Krt17; krt17 {ECO:0000250; PC; PC2; PCHC1; Type I keratin Ka17; UniProtKB:Q04695}
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3872
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.59 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q04695
• Gene Symbols: KRT17
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 133-432 of human Cytokeratin 17 (Cytokeratin 17 (KRT17)) (NP_0004131).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG