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Invitrogen™ Cytokeratin 18 Recombinant Rabbit Monoclonal Antibody (7B2N3)
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Catalog No. PIMA537993
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PIMA537993 100 μL
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Catalog No. PIMA537993 Supplier Invitrogen™ Supplier No. MA537993
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: HeLa, HepG2, A-431 Immunogen sequence: ADIRAQYDEL ARKNREELDK YWSQQIEEST TVVTTQSAEV GAAETTLTEL RRTVQSLEID LDSMRNLKAS LENSLREVEA RYALQMEQLN GILLHLESEL AQTRAEGQRQ AQEYEALLNI KVKLEAEIAT YRRLLEDGED FNLGDALDSS NSMQTIQKTT TRRIVDGKVV SETNDTKVLR H.

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18. Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cytokeratin 18
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone 7B2N3
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene KRT18
Gene Accession No. P05783, P05784, Q5BJY9
Gene Alias cb83; Cell proliferation-inducing gene 46 protein; CK 18; CK18; CK-18; CYK18; cytokeratin 18; cytokeratin endo B; cytokeratin type -1; DAPK-1; Cytokeratin18; cytokeratin-18; dapk1; dorsal aorta proneprin kinesin-1; DreK18; Endo B; I79_023185; K 18; K18; keratin 18; keratin 18, type I; keratin 18a, tandem duplicate 1; keratin complex 1, acidic, gene 18; keratin D; Keratin, type I cytoskeletal 18; Keratin18; keratin-18; Kerd; KRT 18; Krt1-18; KRT18; krt18 {ECO:0000250; krt18a.1; LOC100008885; PIG46; sb:cb83; type I cytoskeletal 18; UniProtKB:P05783}; wu:fa13f02; wu:fb36b04
Gene Symbols KRT18
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 250-430 of human Cytokeratin 18 (KRT18) (P05783).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16668, 294853, 3875
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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