Invitrogen™ Cytokeratin 19 Monoclonal Antibody (4E8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA515884

Catalog No. PIMA515884

Description

MA5-15884 targets KRT19 in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human samples. The MA5-15884 immunogen is purified recombinant fragment of human KRT19 expressed in E. Coli. . MA5-15884 detects KRT19 which has a predicted molecular weight of approximately 41kDa.

Cytokeratin 19 is part of a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight from 40-68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. For example, cytokeratin 19 is not expressed in hepatocytes, therefore, it is useful in the identification of liver metastasis.

Specifications

• Antigen: Cytokeratin 19
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.03% sodium azide
• Gene Accession No.: P08727
• Gene Symbols: KRT19
• Immunogen: Purified recombinant fragment of human KRT19 expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 3880
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 4E8
• Conjugate: Unconjugated
• Gene: KRT19
• Gene Alias: 40-kDa keratin intermediate filament; AI663979; C K1CS; CK 19; CK19; CK-19; cytokeratin 19; cytokeratin-19; EndoC; K19; K1CS; Ka19; keratin 19; keratin 19, type I; keratin complex 1, acidic, gene 19; keratin, type I cytoskeletal 19; keratin, type I, 40-kd; keratin-19; Krt-1.19; Krt1-19; Krt19; LOC100344434; MGC15366; Type I keratin Ka19
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1