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Invitrogen™ Cytokeratin 19 Monoclonal Antibody (JZ202)
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Catalog No. PIMA190953
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250 μL
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PIMA190953 250 μL
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Catalog No. PIMA190953 Supplier Invitrogen™ Supplier No. MA190953
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Description

Mouse Monoclonal Antibody

For IHC, use a streptavidin-biotin system or polymer system, incubating for 30 minutes at room temperature. Store as a concentrated solution. Centrifuge briefly prior to opening vial.

Cytokeratin 19 is part of a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight from 40-68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. For example, cytokeratin 19 is not expressed in hepatocytes, therefore, it is useful in the identification of liver metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cytokeratin 19
Applications Immunohistochemistry (Frozen), Immunocytochemistry
Classification Monoclonal
Clone JZ202
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide; pH 7.4
Gene KRT19
Gene Accession No. P08727
Gene Alias 40-kDa keratin intermediate filament; AI663979; C K1CS; CK 19; CK19; CK-19; cytokeratin 19; cytokeratin-19; EndoC; K19; K1CS; Ka19; keratin 19; keratin 19, type I; keratin complex 1, acidic, gene 19; keratin, type I cytoskeletal 19; keratin, type I, 40-kd; keratin-19; Krt-1.19; Krt1-19; Krt19; LOC100344434; MGC15366; Type I keratin Ka19
Gene Symbols KRT19
Host Species Mouse
Immunogen Human mammary epithelium, solubilized by detergent.
Purification Method Protein A
Quantity 250 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3880
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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