Invitrogen™ Cytokeratin 6 Monoclonal Antibody (Ks6.KA12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA135561

Catalog No. 01-671-399

Description

The antibody represents an excellent marker for non-keratinized squamous epithelia and proliferating cells of epidermis (e.g. within psoriatic lesions).Polypeptide Reacting: Mr 56 000 polypeptide (cytokeratin 6) of human squamous epithelia. Tissues and Tumors specifically detected: The antibody is suitable for discrimination of keratinizing and non-keratinizing squamous cell carcinoma versus e.g. poorly differentiated adenocarcinoma.

Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

Specifications

• Antigen: Cytokeratin 6
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: PBS with 0.5% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P02538, P04259, P48668, P50446, Q9Z331
• Gene Symbols: KRT6A, KRT6B, KRT6C
• Immunogen: Keratin K6 of human callus cytoskeletal preparation.
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Clone: Ks6.KA12
• Conjugate: Unconjugated
• Gene: KRT6A
• Gene Alias: 2310016L08Rik; 60-kDa keratin; BB144589; CK6A; CK-6A; CK6B; CK-6B; CK6C; CK-6C; CK6D; CK-6D; CK-6E; cytokeratin 6A; cytokeratin 6B; cytokeratin 6C; cytokeratin 6D; cytokeratin-6A; Cytokeratin-6B; cytokeratin-6C; Cytokeratin-6D; Cytokeratin-6E; Hom s 5; K6A; K6a keratin; K6B; K6C; K6D; K6E; kamp-keratin derived antimicrobial peptide; KDAMP; Ker2; keratin 6A; keratin 6A, , type II; keratin 6A, type II; keratin 6B; keratin 6B, type II; keratin 6C; keratin 6C, type II; keratin 6E; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6b; keratin complex 2, basic, gene 6c; keratin complex 2, gene 6a; keratin K6; keratin K6h; keratin, epidermal type II, K6A; keratin, epidermal, type II, K6B; keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6B; keratin, type II cytoskeletal 6C; keratin-6A; Keratin-6-alpha; Keratin-6B; keratin-6-beta; keratin-6C; keratin-like 1 (a type II keratin sequence); Krt2-6; Krt2-6a; Krt2-6b; Krt2-6c; Krt6; Krt6a; Krt6b; KRT6C; KRT6D; KRT6E; KRTL1; LOC683313; mK6[a]; mK6[b]; MK6a; mK6-alpha; mK6-beta; PC2; PC3; PC4; PPKNEFD; similar to keratin complex 2, basic, gene 6a; type-II keratin Kb10; Type-II keratin Kb12; type-II keratin Kb6
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 16687, 16688, 286887, 3853, 3854
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov