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Cytokeratin 8 Monoclonal Antibody (LP3K), FITC, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

$520.00

Specifications

Antigen Cytokeratin 8
Clone LP3K
Concentration 0.5 mg/mL
Classification Monoclonal
Conjugate FITC
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-100-84
Encompass_Preferred
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Invitrogen™
11993882
100 μg
Each of 1 for $520.00
Only null left
Edge
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Description

Description

Description: This LP3K monoclonal antibody reacts with human cytokeratin 8 (K8), a 55-kDa member of the family of intermediate filament proteins. Cytokeratin 8 is a type II (or basic) keratin that is expressed in epithelial and carcinoma cells. Cytokeratins form the intracellular cytoskeletal network that maintains the integrity and stability of cells and tissues. More specifically, studies have demonstrated the involvement of cytokeratin 8 in protection against apoptosis, stress, or injury, as well as regulation of the cell cycle. This keratin is frequently co-expressed with cytokeratin 18, a type I (or acidic) keratin as a heterodimer. Although detected primarily in the cytoplasm of normal healthy cells, cytokeratin 8 has been found to localize to the plasma membrane in some tumor cells. Finally, cytokeratin 8 is phosphorylated on serine 73 in dividing cells. Applications Reported: This LP3K antibody has been reported for use in immunofluorescent microscopy. Applications Tested: This LP3K antibody has been tested by immunofluorescent staining of methanol-fixed MCF-7 cells. This can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
Specifications

Specifications

Cytokeratin 8
0.5 mg/mL
FITC
Mouse
Human
3856
IgG1
Affinity Chromatography
Antibody
LP3K
Monoclonal
Liquid
RUO
P05787
KRT8
Primary
4°C, store in dark, DO NOT FREEZE!
KRT8
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.

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