Invitrogen™ Cytokeratin 81/86 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104293

Catalog No. PIPA5104293

Description

Antibody detects endogenous levels of total KRT81/86.

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.

Specifications

• Antigen: Cytokeratin 81/86
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KRT86
• Gene Alias: ghHb1; ghHKb1; hair keratin K2.11; Hair keratin K2.9; hard keratin, type II, 1; hard keratin, type II, 6; Hb1; Hb-1; HB6; hHAKB2-1; K81; K86; keratin 81; keratin 81, type II; keratin 86; keratin 86, type II; keratin protein HB6; keratin, hair, basic, 1; keratin, hair, basic, 6 (monilethrix); keratin, type II cuticular Hb1; Keratin, type II cuticular Hb6; keratin-81; Keratin-86; KRT81; KRT86; KRTHB1; KRTHB6; Metastatic lymph node 137 gene protein; MLN 137; MLN137; MNX; Type II hair keratin Hb1; type II hair keratin Hb6; Type-II keratin Kb21; type-II keratin Kb26
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16679, 3887, 3892, 64818
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O43790, P97861, Q14533, Q9ERE2
• Gene Symbols: KRT81, KRT86
• Immunogen: A synthesized peptide derived from human KRT86(Accession O43790), corresponding to amino acid residues V261-H311.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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