Cytokeratin, pan Mouse anti-Human, Mouse, Rat, Bovine, Canine, Several Species, Alexa Fluor 750, Clone: AE1+ AE3, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP233200AF750
DescriptionCytokeratin, pan Monoclonal antibody specifically detects Cytokeratin, pan in Human, Mouse, Rat, Bovine, Canine, Chicken, Primate, Rabbit, Reptile samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen), Immunofluorescence.
|AE1 + AE3|
|Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), Immunofluorescence|
|Bovine, Canine, Chicken, Human, Mouse, Primate, Rabbit, Rat, Reptile|
|Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot|
|Alexa Fluor™ 750|
|50 mM sodium borate with 0.05% sodium azide|
|Total keratin isolated from human epidermal callus was used as immunogen to generate the pan cytokeratin antibodies AE1 + AE3 (Woodcock-Mitchell, 1982).|
|Protein A or G purified|
|Store at 4°C in the dark.|
|Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which include CK1, CK3, CK4, CK5, CK6, CK8, CK10, CK14, CK15, CK16, and CK19. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.|
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