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Tocris Bioscience™ CZC 25146
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Catalog No. 607110
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60-711-0 10 mg
60-715-0 50 mg
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Catalog No. 60-711-0 Supplier Tocris Bioscience™ Supplier No. 6071/10
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Description

Potent LRRK2 inhibitor

CZC 25146 is a potent LRRK2 inhibitor (IC50 values are 4.76 and 6.87 nM for for wild-type and G2019S mutant forms of LRRK2, respectively). Also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2. Attenuates mutant LRRK2-induced injury of cultured rodent and human neurons. Cell permeable.

Specifications

Chemical Name or Material CZC 25146
CAS 1191911-26-8
Synonym N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Quantity 10 mg
Solubility Soluble to 100mM in DMSO
Molecular Formula C22H25FN6O4S
Formula Weight 488.54
Physical Form Solid
Color Pale-purple
Product Type Bioactive Small Molecule
Purity >98%
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For Research Use Only.

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