Invitrogen™ D2HGDH Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563269

Catalog No. PIPA563269

Description

Immunogen sequence: PGFAEVLQTF STCKGMLGEI LSAFEFMDAV CMQLVGRHLH LASPVQESPF YVLIETSGSN AGHDAEKLGH FLEHALGSGL VTDGTMATDQ RKVKMLWALR ERITEALSRD GYVYKYDLSL Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.

This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.

Specifications

• Antigen: D2HGDH
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: D2HGDH
• Gene Alias: AA408776; AA408778; AI325464; D2HGD; D2HGDH; D2hgdh {ECO:0000250; D-2-hydroxyglutarate dehydrogenase; D-2-hydroxyglutarate dehydrogenase, mitochondrial; FLJ42195; LOW QUALITY PROTEIN: D-2-hydroxyglutarate dehydrogenase, mitochondrial; MGC25181; RGD1307976; UniProtKB:Q8N465}
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 728294
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8N465
• Gene Symbols: D2HGDH
• Immunogen: Recombinant protein corresponding to Human D2HGDH. Recombinant protein control fragment (Product #RP-98926).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov