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Invitrogen™ DAAM1 Polyclonal Antibody
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Catalog No. PIPA5109614
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100 μL
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PIPA5109614 100 μL
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Catalog No. PIPA5109614 Supplier Invitrogen™ Supplier No. PA5109614
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FKKKFAERVA EVKPKVEAIR SGSEEVFRSG ALKQLLEVVL AFGNYMNKGQ RGNAYGFKIS SLNKIADTKS SIDKNITLLH YLITIVENKY PSVLNLNEEL RDIPQAAKVN MTELDKEIST LRSGLKAVET ELEYQKSQPP QPGDKFVSVV SQFITVASFS FSDVEDLLAE AKDLFTKAVK HFGEEAGKIQ PDEFFGIFDQ FLQAVSEAKQ ENENMRKKKE EEERRARMEA QLKEQRERER KMRKAKENSE ESGEFDDLVS ALRSGEVFDK DLSKLKRNRK RITNQMTDSS RERPITKLNF.

DAAM1 is a diaphanous-related formin first studied as a novel Disheveled binding protein and shown to be crucial for the planar cell polarity pathway in Xenopus. DAAM1, like other formins, directs nucleation and elongation of new actin filaments using its conserved formin-homology-2 (FH2) domain. It is a Rho-regulated formin implicated in neuronal development and regulation of gastrulation. It was identified as a binding protein of the Wnt receptor-associated protein Disheveled. It also binds the GTP-bound RhoA and increases its GTP-bound form population in cells. It exists in an autoinhibited state via intramolecular interactions between its amino-terminal GBD and carboxyl-terminal DAD domains. Structurally the protein includes a GTPase-binding domain (GBD), a diaphanous inhibitory domain (DID), and a coiled-coil region followed by the FH1, FH2 and C-terminal diaphanous auto-regulatory domain (DAD). In humans, the DAAM1 gene is mapped to chromosome 14q23.1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DAAM1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.84 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene DAAM1
Gene Accession No. Q8BPM0, Q9Y4D1
Gene Alias Daam1; Disheveled-associated activator of morphogenesis 1; dishevelled associated activator of morphogenesis 1; I79_021650; KIAA0666
Gene Symbols DAAM1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 769-1068 of human DAAM1 (NP_001257449.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 208846, 23002, 314212
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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