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Tocris Bioscience™ Dabrafenib mesylate
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Catalog No. 722350
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50 mg
Catalog No. Quantity
72-235-0 50 mg
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Catalog No. 72-235-0

Supplier: Tocris Bioscience™ 7223/50

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Description

Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome

Dabrafenib mesylate is a potent and selective Raf kinase inhibitor (IC50 values are 0.8, 3.2 and 5.0 nM for B-RafV600E, wild-type B-Raf and c-Raf, respectively). Exhibits selectivity for B-Raf over a panel of 270 other kinases. Arrests cell cycle in the G1 phase and inhibits growth of B-RafV600E mutant melanoma and colon cancer cells in vitro and in vivo. Orally bioavailable. Also inhibits NEK9 (IC50 <10 nM) and CDK16. Identified as targeting human host proteins that interact with SARS-CoV-2.

Specifications

Chemical Name or Material N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide methanesulfonate
CAS 1195768-06-9
Quantity 50 mg
Target Raf Kinase Inhibitors
Molecular Formula C23H20F3N5O2S2.CH3SO3H
Purity 0.98
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