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Invitrogen™ DACH1 Polyclonal Antibody
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Catalog No. PIPA523483
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100 μg
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Catalog No. Quantity
PIPA523483 100 μg
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Catalog No. PIPA523483 Supplier Invitrogen™ Supplier No. PA523483
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Description

Rabbit Polyclonal Antibody

The amino acid sequence used as immunogen is 83% homologous in Zebrafish.

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DACH1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene Dach1
Gene Accession No. Q9QYB2, Q9UI36
Gene Alias Dac; dac homolog; DACH; Dach1; dachshund 1; dachshund 1 (Drosophila); dachshund family transcription factor 1; dachshund homolog 1; FLJ10138; OTTHUMP00000040839; RP11-512J14.1
Gene Symbols Dach1
Host Species Rabbit
Immunogen Amino acids 474-501 of human Dach1.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100065685, 13134, 1602, 373935, 485489, 537184
Target Species Human, Mouse, Canine, Monkey, Bovine, Horse, Chicken
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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