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DACH1 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501565462
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50-156-5462 20 μL
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Catalog No. 50-156-5462 Supplier Bethyl Laboratories, Inc Supplier No. A303556AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predict

Dachshund homolog 1 belongs to the DACH/Dachshund family. It is a transcription factor involved in the regulation of organogenesis. DACH1 plays a role in retinal and pituitary precursor cell proliferation.It is reported to be expressed in breast cancer cell lines and to inhibit transforming growth factor-beta (TGF-beta)-induced apoptosis. DACH1 repressed TGF-beta induction of AP-1 and Smad signaling in gene reporter assays and repressed endogenous TGF-beta-responsive genes by microarray analyses. DACH1 participates in the negative regulation of TGF-beta signaling by interacting with NCoR and Smad4. Mouse DACH1 protein was immunolocalized to specific cell types within the developing kidneys, eyes, cochleae, and limb buds.

Specifications

Antigen DACH1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene DACH1
Gene Accession No. Q9UI36
Gene Alias OTTHUMP00000040839; dachshund homolog 1 (Drosophila) ; DACH1; RP11-512J14.1; DACH; FLJ10138; dachshund homolog 1
Gene Symbols DACH1
Host Species Rabbit
Immunogen Between 740 and 760
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1602
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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