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Invitrogen™ DACT2 Polyclonal Antibody
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Catalog No. PIPA556414
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100 μL
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PIPA556414 100 μL
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Catalog No. PIPA556414 Supplier Invitrogen™ Supplier No. PA556414
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DKVLRFARQP LLLLDRPEGA HAAPQPSLEW DPAHWPTGRG GLQRRPALAW EAPGRSCSES TL Highest antigen sequence identity to the following orthologs: Mouse - 39%, Rat - 52%.

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors. At least two isoforms of Dact2 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DACT2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DACT2
Gene Accession No. Q5SW24
Gene Alias 2900084M21Rik; A630024E20; bA503C24.7; C6orf116; Dact2; Dapper antagonist of catenin 2; dapper homolog 2; dapper homolog 2, antagonist of beta-catenin; dapper homolog 2, antagonist of beta-catenin (xenopus); dapper, antagonist of beta-catenin, homolog 2; DAPPER2; dishevelled binding antagonist of beta catenin 2; dishevelled-binding antagonist of beta-catenin 2; Dpr2; Frd2; mDpr2; PP13671; RP11-503C24.7
Gene Symbols DACT2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DACT2. Recombinant protein control fragment (Product #RP-94930).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 168002
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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