Invitrogen™ DACT2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556415

Catalog No. PIPA556415

Description

Immunogen sequence: PWGTFWPRPV STGDLDRALP ADTGLQKASA DAELLGLLCQ GVDIPLHVPD PKYRQDLVSQ GGREVYPYPS PLHAVALQSP LFVLTKETPQ Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 70%.

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors. At least two isoforms of Dact2 are known to exist.

Specifications

• Antigen: DACT2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DACT2
• Gene Alias: 2900084M21Rik; A630024E20; bA503C24.7; C6orf116; Dact2; Dapper antagonist of catenin 2; dapper homolog 2; dapper homolog 2, antagonist of beta-catenin; dapper homolog 2, antagonist of beta-catenin (xenopus); dapper, antagonist of beta-catenin, homolog 2; DAPPER2; dishevelled binding antagonist of beta catenin 2; dishevelled-binding antagonist of beta-catenin 2; Dpr2; Frd2; mDpr2; PP13671; RP11-503C24.7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 168002
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5SW24
• Gene Symbols: DACT2
• Immunogen: Recombinant protein corresponding to Human DACT2. Recombinant protein control fragment (Product #RP-94929).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG